- From Milan: Highway A14 (Bologna-Ancona-Pescara); exit Grottammare.
- From Rome: Highway A24 (Rome-L’Aquila-Teramo); exit Teramo, Highway A14 (Towards Ancona); exit Grottammare.
From Grottammare’s toll booth turn right towards Ripatransone-Valtesino; continue for 4.3 km until Valtesino’s main road; turn left and continue for 5 km until you take a left at the Acquaviva, Monsapolo, San Savino sign. At the 3.3 km mark, on the left, you’ll find a gravel road that will take you to “L’Ape Regina”.
Train station S. Benedetto del Tronto. Taxi from station about 10 km to L’Ape Regina.
Ancona’s airport 90 km
Pescara’s airport 60 km